Sal\u0131\u2019dan (07.12.2021) \u00c7ar\u015famba (08.12.2021) g\u00fcn\u00fcne ge\u00e7i\u015fte omikron varyant\u0131n\u0131n ba\u011f\u0131\u015f\u0131kl\u0131ktan ka\u00e7ma yetene\u011fine y\u00f6nelik \u00fc\u00e7 \u00e7al\u0131\u015fman\u0131n \u00f6n sonu\u00e7lar\u0131 internet \u00fczerinden pe\u015f pe\u015fe payla\u015f\u0131ld\u0131:<\/strong><\/em><\/p>\nG\u00fcney Afrika Sa\u011fl\u0131k Ara\u015ft\u0131rmalar\u0131 Enstit\u00fcs\u00fc (AHRI)\u2019den Alex Sigal ve ekibinin ger\u00e7ek virus kullanarak k\u0131s\u0131tl\u0131 say\u0131da serum \u00f6rne\u011fi \u00fczerinde ger\u00e7ekle\u015ftirdikleri birinci \u00e7al\u0131\u015fmada, iki doz BioNTech (BTN162b2) a\u015f\u0131s\u0131 sonras\u0131 sa\u011flanan antikorlar\u0131n omikrona kar\u015f\u0131 n\u00f6tralizasyon kapasitesi orijinal k\u00f6kene k\u0131yasla 40 kat azalm\u0131\u015f bulunurken; do\u011fal infeksiyon sonras\u0131 a\u015f\u0131lanm\u0131\u015f ki\u015filerde ise bu d\u00fc\u015f\u00fc\u015f\u00fcn daha az oldu\u011fu saptanm\u0131\u015ft\u0131r.<\/p>\n
\u0130sve\u00e7 Karolinska Enstit\u00fcs\u00fc ve G\u00fcney Afrika Cape Town \u00dcniversitesi\u2019nden ara\u015ft\u0131rmac\u0131lar\u0131n ortakla\u015fa yapt\u0131\u011f\u0131 2. \u00e7al\u0131\u015fmadaysa, D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc\u2019n\u00fcn referans serumunun omikrona kar\u015f\u0131 aktivitesi yine 40 kat azalm\u0131\u015f olarak bulunmu\u015ftur. Kan don\u00f6rleri ve daha \u00f6nce COVID-19 ge\u00e7irmi\u015f ve a\u015f\u0131lanm\u0131\u015f sa\u011fl\u0131k \u00e7al\u0131\u015fanlar\u0131n\u0131n serum \u00f6rneklerinin \u00e7o\u011fu omikron varyant\u0131na kar\u015f\u0131 aktivitesini korumakla birlikte omikronu n\u00f6trleme kapasitelerinin s\u0131ras\u0131 ile 7 ve 5 kat azalm\u0131\u015f oldu\u011fu sonucu elde edilmi\u015ftir. Ancak bu sonu\u00e7lar\u0131n \u00f6n sonu\u00e7lar oldu\u011fu ve do\u011frulanaca\u011f\u0131 belirtilmektedir. Ayr\u0131ca bu \u00e7al\u0131\u015fmada ger\u00e7ek vir\u00fcs yerine ps\u00f6dovirus kullan\u0131lm\u0131\u015ft\u0131r. Ger\u00e7ek virusle yapt\u0131klar\u0131 denemelerde belirgin d\u00fc\u015f\u00fc\u015fler g\u00f6zledikleri de ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan belirtilmi\u015ftir.<\/p>\n
Frankfurt Goethe \u00dcniversitesi\u2019nde T\u0131bbi Viroloji Enstit\u00fcs\u00fc Ba\u015fkan\u0131 Sandra Ciesek ve ekibinin yapt\u0131\u011f\u0131 3.\u00e7al\u0131\u015fman\u0131n \u00f6n sonu\u00e7lar\u0131 Profes\u00f6r Ciesek\u2019in twitter hesab\u0131ndan payla\u015f\u0131lm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 da ilk \u00e7al\u0131\u015fma ile \u00f6rt\u00fc\u015fmekte olup iki doz BioNTech veya Moderna a\u015f\u0131s\u0131 yap\u0131lm\u0131\u015f ki\u015filerde n\u00f6trleme kapasitesinin s\u0131f\u0131rland\u0131\u011f\u0131n\u0131, BioNTech hat\u0131rlatma dozu yap\u0131lm\u0131\u015f olanlar\u0131n %25\u2019inde n\u00f6trleyici antikorlar\u0131n var oldu\u011funu g\u00f6stermektedir. Rutin olarak \u00f6nerilen 2 dozluk birincil a\u015f\u0131lama \u015femalar\u0131ndan sonraki d\u00fc\u015f\u00fc\u015f bu \u00e7al\u0131\u015fmada da 37 kat olarak saptanm\u0131\u015ft\u0131r.<\/p>\n
Yukar\u0131da \u00f6zetlenmi\u015f her \u00fc\u00e7 \u00e7al\u0131\u015fma da \u00f6zellikle 2 doz a\u015f\u0131lama sonras\u0131 elde edilen antikor yan\u0131tlar\u0131n\u0131n omikron varyant\u0131na kar\u015f\u0131 etkili olamayabilece\u011fini, ge\u00e7irilmi\u015f infeksiyon+a\u015f\u0131lama ya da 3. doz uygulamalar\u0131 ile elde edilen antikorlar\u0131n omikrona kar\u015f\u0131 aktivitelerini bir \u00f6l\u00e7\u00fcye kadar koruduklar\u0131n\u0131 g\u00f6stermektedir. Bu veriler, primer a\u015f\u0131laman\u0131n omikrona ba\u011fl\u0131 \u00f6zellikle a\u011f\u0131r hastal\u0131k ve \u00f6l\u00fcm riskini azaltmada da yetersiz olaca\u011f\u0131 anlam\u0131na gelmemektedir.<\/p>\n
Bu konuda kesin bir yarg\u0131ya varabilmek i\u00e7in ek \u00e7al\u0131\u015fmalar gereklidir. \u00dc\u00e7\u00fcnc\u00fc dozlar\u0131n korunma a\u00e7\u0131s\u0131ndan \u00f6nemli oldu\u011fu g\u00f6r\u00fc\u015f\u00fc genel olarak payla\u015f\u0131lmakla birlikte bu konuda da daha fazla verinin ortaya \u00e7\u0131kmas\u0131na gereksinim vard\u0131r. \u00d6zellikle G\u00fcney Afrika\u2019da daha \u00f6nceki dalgalarda vaka say\u0131lar\u0131n\u0131n \u00e7ok y\u00fcksek olmas\u0131ndan dolay\u0131 toplumun \u00fc\u00e7te ikisinin do\u011fal infeksiyon sonucu antikor geli\u015ftirdikleri d\u00fc\u015f\u00fcn\u00fclmektedir.<\/p>\n
Deltaya kar\u015f\u0131 6 kata kadar daha bula\u015f\u0131c\u0131 oldu\u011fu hesaplanan omikronun ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 y\u00fcksek bir toplumdaki yay\u0131l\u0131m\u0131n\u0131n, bu \u00fc\u00e7 \u00e7al\u0131\u015fma ile de bir \u00f6l\u00e7\u00fcde desteklenmi\u015f olan antikorlardan ka\u00e7ma yetene\u011fiyle kolayla\u015ft\u0131\u011f\u0131 s\u00f6ylenebilir. Ayn\u0131 zamanda, bu yeni varyant\u0131n infekte edebildi\u011fi ki\u015filerde \u00f6nceden var olan ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n, hastal\u0131\u011f\u0131n daha hafif ge\u00e7mesine de katk\u0131 sa\u011flayabilece\u011fi d\u00fc\u015f\u00fcn\u00fclebilir.<\/p>\n
Kaynak: Haber Global<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
Sa\u011fl\u0131k Bakan\u0131 Fahrettin Koca ‘omicron’ varyant\u0131n\u0131n T\u00fcrkiye’de g\u00f6r\u00fcld\u00fc\u011f\u00fcn\u00fc belirterek “Bunlardan 1’i \u0130stanbul 5’i \u0130zmir’de. Bu 6 vakan\u0131n hastane ihtiyac\u0131 olmad\u0131….<\/p>\n","protected":false},"author":2,"featured_media":30288,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-30287","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/30287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/comments?post=30287"}],"version-history":[{"count":0,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/30287\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media\/30288"}],"wp:attachment":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media?parent=30287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/categories?post=30287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/tags?post=30287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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