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D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (DS\u00d6) verilerine g\u00f6re; d\u00fcnyada 55 milyonu a\u015fk\u0131n demans (bunama) hastas\u0131 bulunuyor. Bu say\u0131n\u0131n 2030 y\u0131l\u0131na kadar 78 milyona \u00e7\u0131kmas\u0131 bekleniyor. \u0130nsanlar\u0131n ya\u015fam kalitesini \u00f6nemli derecede d\u00fc\u015f\u00fcren bu hastal\u0131kta erken te\u015fhis b\u00fcy\u00fck bir \u00f6nem ta\u015f\u0131yor.<\/p>\n
\u0130ngiliz bilim insanlar\u0131, demans hastal\u0131\u011f\u0131na kar\u015f\u0131 b\u00fcy\u00fck bir ad\u0131m att\u0131 ve bir a\u015f\u0131 geli\u015ftirdiklerini duyurdu. <\/p>\n
Bilim insanlar\u0131 demans hastal\u0131\u011f\u0131n\u0131n, amiloid beta ad\u0131 ve do\u011fal olarak olu\u015fan proteinlerin beyinde plaklar olu\u015fturmas\u0131yla meydana geldi\u011fini a\u00e7\u0131klad\u0131. NTV’nin aktard\u0131\u011f\u0131 habere g\u00f6re; ara\u015ft\u0131rmac\u0131lar, k\u0131salt\u0131lm\u0131\u015f toksik amiloid beta formuna ba\u011flanan ve molek\u00fcllerin plaklar olu\u015fturmak \u00fczere bir araya gelmesini \u00f6nleyen TAP01-04 adl\u0131 bir antikor tan\u0131mlad\u0131. <\/p>\n
Bu antikor, umut verici yeni tedavinin temelini olu\u015fturuyor. Alzheimer hastal\u0131\u011f\u0131 olan fareler \u00fczerinde yap\u0131lan denemeler, antikorun, daha az plak olu\u015ftu\u011fu i\u00e7in beyin h\u00fccrelerinin i\u015flevini geri kazanmaya yard\u0131mc\u0131 oldu\u011funu ve haf\u0131zay\u0131 iyile\u015ftirdi\u011fini buldu.<\/p>\n
A\u015eI YAKINDA GELEB\u0130L\u0130R<\/h2>\n
Bununla birlikte \u00e7al\u0131\u015fman\u0131n arkas\u0131ndaki ara\u015ft\u0131rmac\u0131lar, v\u00fccudu TAP01-04 antikorlar\u0131 \u00fcretmesi i\u00e7in tetikleyen ve y\u0131l gibi k\u0131sa bir s\u00fcrede demans riski y\u00fcksek insanlara sunulabilecek bir a\u015f\u0131 \u00fczerinde \u00e7al\u0131\u015ft\u0131klar\u0131n\u0131 s\u00f6yledi.<\/p>\n
Ekip, farelerde yap\u0131lan \u00e7al\u0131\u015fmalar\u0131n\u0131n, yaln\u0131zca olu\u015fmu\u015f plaklar\u0131 tedavi etmek yerine, Alzheimer’\u0131n ilk etapta \u00f6nlenebilece\u011fini g\u00f6sterdi\u011fini s\u00f6yledi.<\/p>\n
\u00c7al\u0131\u015fmay\u0131 y\u00fcr\u00fcten Prof. Dr. Mark Carr, “\u00c7al\u0131\u015fma hala erken bir a\u015famada olsa da, bu sonu\u00e7lar insan klinik deneylerinde tekrarlan\u0131rsa, devrim niteli\u011finde olabilir. Bulgular, demans\u0131n\u0131 yaln\u0131zca semptomlar tespit edildi\u011finde tedavi edilebilece\u011fini de\u011fil, ayn\u0131 zamanda semptomlar ortaya \u00e7\u0131kmadan \u00f6nce de \u00f6nlenebilece\u011fini g\u00f6steriyor.<\/p>\n
YAN ETK\u0130S\u0130 BULUNMUYOR<\/h2>\n
Di\u011fer taraftan, Almanya’daki G\u00f6ttingen \u00dcniversitesi T\u0131p Merkezi’nden yard\u0131mc\u0131 yazar Profes\u00f6r Thomas Bayer, “Klinik deneylerde, beyindeki amiloid plaklar\u0131 \u00e7\u00f6zen potansiyel tedavilerin hi\u00e7biri demans semptomlar\u0131n\u0131 azaltma a\u00e7\u0131s\u0131ndan \u00e7ok fazla ba\u015far\u0131 g\u00f6stermedi.<\/p>\n
‘Baz\u0131lar\u0131nda olumsuz yan etkiler bile ya\u015fand\u0131. Bu y\u00fczden farkl\u0131 bir yakla\u015f\u0131ma karar verdik. Farelerde, \u00e7\u00f6z\u00fcn\u00fcr amiloid betan\u0131n budanm\u0131\u015f bi\u00e7imlerini n\u00f6tralize edecek, ancak ne proteinin normal bi\u00e7imlerine ne de plaklara ba\u011flanmayacak bir antikor belirledik\u201d diyerek \u00e7al\u0131\u015fman\u0131n \u00f6nemine vurgu yapt\u0131.<\/p>\n
\u00d6te yandan \u00e7al\u0131\u015fman\u0131n, t\u0131bbi ara\u015ft\u0131rma yard\u0131m kurulu\u015fu LifeArc ile ortakla\u015fa y\u00fcr\u00fct\u00fcld\u00fc\u011f\u00fc bildirildi. Ara\u015ft\u0131rman\u0131n t\u00fcm sonu\u00e7lar\u0131 Molecular Psychiatry dergisinde yay\u0131mland\u0131.<\/p>\n
Kaynak: Haber Global<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"
\u0130ngiltere\u2019de ara\u015ft\u0131rmac\u0131lar, demans (bunama) hastal\u0131\u011f\u0131n\u0131n ilerlemesini durdurabilecek, hatta hastal\u0131\u011f\u0131 \u00f6nleyebilecek bir tedavi geli\u015ftirdiklerini duyurdu.\u00a0Uzmanlar, insanlardaki denemelerin \u00e7ok yak\u0131nda ba\u015flayaca\u011f\u0131n\u0131 a\u00e7\u0131klad\u0131….<\/p>\n","protected":false},"author":2,"featured_media":25749,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-25748","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik"],"_links":{"self":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/25748","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/comments?post=25748"}],"version-history":[{"count":0,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/25748\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media\/25749"}],"wp:attachment":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media?parent=25748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/categories?post=25748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/tags?post=25748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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