koronavir\u00fcs<\/a> a\u015f\u0131s\u0131n\u0131 alan ilk hasta Margaret Keenan, 8 Aral\u0131k 2020\u2019de, 90 ya\u015f\u0131ndayken klinik bir deney d\u0131\u015f\u0131nda koronavir\u00fcs a\u015f\u0131s\u0131 yapt\u0131ran ve Pfizer\/BioNTech a\u015f\u0131s\u0131n\u0131 olan d\u00fcnyadaki ilk ki\u015fi olarak tarihe ge\u00e7mi\u015fti.<\/p>\nMargaret, \u00f6nceki g\u00fcn de g\u00fc\u00e7lendirici olarak adland\u0131r\u0131lan 3. doz BioNTech a\u015f\u0131s\u0131n\u0131 yapt\u0131rd\u0131.<\/p>\n
H\u00fcrriyet’ten Sedef Bat\u0131 ve Selin Irmak Ka\u00e7maz’\u0131n haberine g\u00f6re Maggie, d\u00fcnyada ilk koronavir\u00fcs a\u015f\u0131s\u0131n\u0131 olarak tarihe ge\u00e7ti\u011fi hastanede, \u00dc\u00e7\u00fcnc\u00fc Doz a\u015f\u0131s\u0131n\u0131 da olurken yine yan\u0131nda hem\u015fire May Parsons\u2019a vard\u0131. Ancak bir farkla; Parsons bu kez a\u015f\u0131y\u0131 yapan ki\u015fi de\u011fildi. \u0130kili, \u00fc\u00e7\u00fcnc\u00fc g\u00fc\u00e7lendirici dozlar\u0131n\u0131 yan yana oldu. A\u015f\u0131 olman\u0131n bir toplumsal sorumluluk oldu\u011funun da alt\u0131n\u0131 \u00e7izen Keenan, \u201c\u0130nsanlar bunu kendileri i\u00e7in yapmasalar, sa\u011fl\u0131kl\u0131 ve g\u00fc\u00e7l\u00fc olsalar bile, savunmas\u0131z olan di\u011fer insanlar i\u00e7in yapmal\u0131lar. Bunu y\u00fcksek sesle s\u00f6ylemek gerekiyor ki; a\u015f\u0131 olmak toplumsal bir sorumluluktur\u201d \u015feklinde konu\u015ftu.<\/p>\n
Sa\u011fl\u0131k Bakan\u0131 Fahrettin Koca, 30 Haziran’daki Koronavir\u00fcs Bilim Kurulu toplant\u0131s\u0131n\u0131n ard\u0131ndan yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, iki doz Sinovac a\u015f\u0131s\u0131 olmu\u015f 50 ya\u015f ve \u00fczerindekiler ile sa\u011fl\u0131k \u00e7al\u0131\u015fanlar\u0131n\u0131n 1 Temmuz’dan itibaren \u00fc\u00e7\u00fcnc\u00fc dozlar\u0131n\u0131 olmak \u00fczere randevu alabileceklerini bildirmi\u015fti.<\/p>\n
\u00d6zellikle yurt d\u0131\u015f\u0131na \u00e7\u0131kacaklar\u0131n, a\u015f\u0131 kart\u0131 sebebi ile 2 doz Sinovac olsa dahi 2 doz da BioNTech olmas\u0131 gerekiyordu. Bunun yan\u0131 s\u0131ra \u00fc\u00e7\u00fcnc\u00fc doz se\u00e7imi yine ki\u015finin kendi tercihine b\u0131rak\u0131ld\u0131. \u0130steyenler \u00fc\u00e7\u00fcnc\u00fc dozlar\u0131n\u0131 BioNTech, isteyenler ise Sinovac yapt\u0131rd\u0131.<\/p>\n
2 doz Sinovac a\u015f\u0131s\u0131n\u0131 olanlar\u0131n g\u00fc\u00e7lendirici \u00fc\u00e7\u00fcnc\u00fc dozu almas\u0131n\u0131n ard\u0131ndan, Sa\u011fl\u0131k Bakan\u0131 Koca 2 doz BioNTech olanlar i\u00e7in de bir a\u00e7\u0131klama yapt\u0131. Koca, mRNA a\u015f\u0131lar\u0131n\u0131n 6 aydan sonra etkinli\u011finin azalabildi\u011fini, bunun i\u00e7in de 2 dozunu tamamlad\u0131ktan en az 6 ay sonras\u0131nda bir g\u00fc\u00e7lendirici doz \u00f6n g\u00f6rd\u00fcklerini s\u00f6yledi.<\/p>\n
T\u00dcRK\u0130YE’DE \u0130LK BIONTECH<\/h2>\n
\u00dclkemizde a\u015f\u0131lama program\u0131 ocak ay\u0131nda Sinovac ile ba\u015flam\u0131\u015ft\u0131. Pfizer\/BioNTech Kovid-19 a\u015f\u0131s\u0131 ise Nisan ay\u0131nda \u00fclkemize gelmi\u015f ve hemen uygulanmaya ba\u015flanm\u0131\u015ft\u0131. \u0130kinci dozlar ise May\u0131s ay\u0131nda yap\u0131ld\u0131. Buna g\u00f6re, BioNTech a\u015f\u0131s\u0131n\u0131 ilk olanlar\u0131n 6 ay\u0131 Kas\u0131m sonunda doluyor. \u00dclkemizde 3. doz BioNTech a\u015f\u0131s\u0131n\u0131n yap\u0131l\u0131p yap\u0131lmayaca\u011f\u0131, ne zaman uygulanaca\u011f\u0131 ise hen\u00fcz bilinmiyor.<\/p>\n
FDA VE CDC ONAYLI<\/h2>\n
Bu konu sadece T\u00fcrkiye\u2019de de\u011fil, t\u00fcm d\u00fcnyada bir numaral\u0131 g\u00fcndemlerden biri. Yap\u0131lan \u00e7al\u0131\u015fmalar ve tart\u0131\u015fmalar sonras\u0131 ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA), ge\u00e7ti\u011fimiz g\u00fcnlerde Pfizer\/BioNTech Kovid-19 a\u015f\u0131s\u0131n\u0131n 65 ya\u015f ve \u00fczerindekiler, a\u011f\u0131r hastal\u0131k riski ta\u015f\u0131yan ki\u015filer ve vir\u00fcse d\u00fczenli olarak maruz kalanlar i\u00e7in \u00fc\u00e7\u00fcnc\u00fc takviye dozunun uygulanmas\u0131n\u0131 onaylad\u0131.<\/p>\n
ABD Hastal\u0131k Kontrol ve \u00d6nleme Merkezleri (CDC) b\u00fcnyesindeki A\u015f\u0131 Uygulamalar\u0131 Dan\u0131\u015fma Komitesi de FDA karar\u0131ndan sonra, 65 ya\u015f \u00fcst\u00fc ile belli hastal\u0131k ve kronik rahats\u0131zl\u0131klar\u0131 olanlara g\u00fc\u00e7lendirici dozu tavsiye etti. \u015eimdi ise d\u00fcnyada yava\u015f yava\u015f 2 doz mRNA a\u015f\u0131s\u0131 olanlara g\u00fc\u00e7lendirici doz uygulanmaya ba\u015fland\u0131. 2 doz mRNA a\u015f\u0131s\u0131 olanlar\u0131n akl\u0131nda bu konuyla ilgili pek \u00e7ok soru var. Konunun uzmanlar\u0131na \u201c\u00dc\u00e7\u00fcnc\u00fc doz BioNTech kimlere ve ne zaman yap\u0131lmal\u0131?\u201d diye sorduk.<\/p>\n
“50 YA\u015e \u00dcST\u00dcNE YAPILMALI”<\/h2>\n
Prof. Dr. Derya Unutmaz: 1. doz Biontech, 2. dozdan en az 6 ay sonra 50 ya\u015f \u00fcst\u00fcne ve kronik hastal\u0131kla Kovid-19 riski olanlara ve sa\u011fl\u0131k personeline yap\u0131lmal\u0131. G\u00fc\u00e7lendirici 3. dozlar ABD\u2019de 65 ya\u015f \u00fcst\u00fcne yap\u0131l\u0131yor ama bence 50 ve \u00fcst\u00fc olmal\u0131. Bunun yan\u0131 s\u0131ra 2 doz Sinovac olanlar\u0131n ise 3 ay sonra 3. doz BioNTech yapt\u0131rmas\u0131 gerekiyor.<\/p>\n
Prof. Dr. Alper \u015eener: FDA 3. doz Biontech i\u00e7in son dozdan sonra 6 ay ge\u00e7mi\u015f olmay\u0131 uygun g\u00f6rd\u00fc \u00e7\u00fcnk\u00fc klinik izlemlerde antikor seviyesi 4. aydan sonra azalmaya ba\u015fl\u0131yor. T\u00fcrkiye\u2019de ayn\u0131 stratejiyi s\u00fcrd\u00fcrmek gerekir ama bizde durum daha karma\u015f\u0131k. \u00dclkemizde 65 ya\u015f \u00fcst\u00fc, iki doz Sinovac \u00fcst\u00fcne \u00fc\u00e7\u00fcnc\u00fcy\u00fc \u00e7o\u011funlukla BioNTech oldular. Yani bizde \u015fu anda hat\u0131rlatma dozu BioNTech olan bir grup var.<\/p>\n
Primer ba\u011f\u0131\u015f\u0131klamas\u0131 BioNTech olanlar 65 ya\u015f alt\u0131nda ve bu durumun de\u011ferlendirmesi zor ancak yine de fikir y\u00fcr\u00fctebiliriz. ABD \u00f6zellikle monoklonal antikor kullananlarda 3 ay a\u015f\u0131lanmay\u0131 \u00f6nermiyor \u00e7\u00fcnk\u00fc kanda yeterli haz\u0131r antikor var. Bu mant\u0131k ile gidersek en az 3 ay bu gruba ba\u015fka bir mRNA a\u015f\u0131s\u0131na gerek yok diyebiliriz. Sonras\u0131 i\u00e7in ise yorum yapmak zor\u2026<\/p>\n
ANT\u0130KOR YANITI<\/h2>\n
Burada bence antikor bakarak ilerleyebiliriz \u00e7\u00fcnk\u00fc antikor yan\u0131t\u0131 herkeste farkl\u0131 olu\u015fuyor ve dolay\u0131s\u0131 ile s\u00fcre de farkl\u0131 oluyor. \u0130ki doz BioNTech olan 65 ya\u015f alt\u0131 grup bizde daha fazla ve bunlara d\u00fcnyada 3. doz uygulanan yer yok. ABD, \u0130srail bunu 50 ya\u015fa \u00e7ekmeyi tart\u0131\u015f\u0131yor ama hala net de\u011fil. ABD\u2019deki uygulama ise \u015f\u00f6yle olacak: 65 ya\u015f \u00fcst\u00fcne, \u00f6n cephede sava\u015fan sa\u011fl\u0131k \u00e7al\u0131\u015fan\u0131, \u00f6\u011fretmen, market \u00e7al\u0131\u015fanlar\u0131na 3. doz yap\u0131lacak. FDA di\u011fer gruplar i\u00e7in \u00f6l\u00fcm\/ hastaneye yat\u0131\u015f oranlar\u0131na ve vir\u00fcsle kar\u015f\u0131la\u015fma riskine bakarak 3. doza gerek g\u00f6rmedi.<\/p>\n
Benim ki\u015fisel g\u00f6r\u00fc\u015f\u00fcme g\u00f6re 2 doz sonras\u0131 6. ayda herkes hat\u0131rlatma dozu olmal\u0131\u2026K\u0131\u015f d\u00f6nemi i\u00e7inde 3. dozu olanlarda \u00f6zellikle 65 ya\u015f \u00fcst\u00fcne, sa\u011fl\u0131k \u00e7al\u0131\u015fan\u0131, \u00f6\u011fretmen, market \u00e7al\u0131\u015fan\u0131\/ hizmet sekt\u00f6r\u00fc grubunda ya\u015ftan ba\u011f\u0131ms\u0131z antikor bakarak son dozdan 3 ay sonra ba\u015flayacak \u015fekilde antikoru d\u00fc\u015f\u00fck olanlara 4. doz planlamas\u0131 yap\u0131lmal\u0131. \u00c7\u00fcnk\u00fc bu k\u0131\u015f sert y\u00fckseli\u015fler g\u00f6rece\u011fiz.<\/p>\n
“65 YA\u015e VE \u00dcZER\u0130 KES\u0130NL\u0130KLE 3. DOZ YAPTIRMALI”<\/h2>\n
Do\u00e7. Dr. \u00dcmit Sava\u015f\u00e7\u0131: 65 ya\u015f \u00fczerine ve \u00f6zellikle ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131l\u0131 hastalara, diyaliz hastalar\u0131na, kalp hastalar\u0131na, KOAH hastalar\u0131na ve sa\u011fl\u0131k \u00e7al\u0131\u015fanlar\u0131na ben de 3. dozu kesinlikle \u00f6neriyorum. \u00d6zellikle \u00fczerinden alt\u0131 ay ge\u00e7tiyse zaten kesinlikle 3. dozu yapt\u0131rmalar\u0131 gerekir.<\/p>\n
Prof. Dr. \u0130ftihar K\u00f6ksal: Bu konu, \u00f6zellikle daha bula\u015f\u0131c\u0131 ve\/veya imm\u00fcn sistemden ka\u00e7an a\u015f\u0131 varyantlar\u0131n\u0131n yayg\u0131n dola\u015f\u0131m\u0131 ile yo\u011fun bir ara\u015ft\u0131rma ve tart\u0131\u015fma konusudur. Pfizer ve BioNTech, a\u015f\u0131 etkinli\u011finin zaman i\u00e7inde azald\u0131\u011f\u0131na dair verileri yay\u0131nlad\u0131. \u0130srail, ilk \u00f6nce a\u015f\u0131lanan ki\u015filerde, a\u015f\u0131laman\u0131n \u00fczerinden uzun s\u00fcre ge\u00e7ti\u011fi i\u00e7in enfekte olma olas\u0131l\u0131\u011f\u0131n\u0131n artt\u0131\u011f\u0131n\u0131 bildirdi. Bu nedenle de ilk a\u015f\u0131lanan grupta yer alan 60 ya\u015f \u00fczeri ki\u015filere ve ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f ki\u015filere \u00fc\u00e7\u00fcnc\u00fc doz Pfizer\/BioNTech a\u015f\u0131s\u0131 uygulamaya ba\u015fland\u0131. \u0130kinci dozdan 6 ay sonra uygulanan rapel dozlarda g\u00fcvenlik a\u00e7\u0131s\u0131ndan bir sorun saptanmam\u0131\u015f olup bu uygulama antikor seviyelerinin \u00e7ok y\u00fcksek d\u00fczeylere ula\u015ft\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir.<\/p>\n
Amerika Hastal\u0131k Kontrol Merkezi (CDC) A\u015f\u0131 Uygulamalar\u0131 Dan\u0131\u015fma Komitesi (ACIP), 22 Temmuz\u2019da, 3. doz a\u015f\u0131lar\u0131n kimlere uygulanaca\u011f\u0131n\u0131n tart\u0131\u015f\u0131ld\u0131\u011f\u0131 bir toplant\u0131 yapt\u0131. Bu toplant\u0131da 3. doz a\u015f\u0131lar\u0131n toplumdaki t\u00fcm bireylere de\u011fil, \u00e7o\u011funlukla ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f insanlara yap\u0131lmas\u0131 konusunda tavsiye karar\u0131 al\u0131nd\u0131.<\/p>\n
“\u00dc\u00c7\u00dcNC\u00dc DOZDA PANDEM\u0130Y\u0130 B\u0130T\u0130REB\u0130L\u0130R\u0130Z”<\/h2>\n
Bu toplant\u0131dan k\u0131sa bir s\u00fcre sonra da ABD G\u0131da ve \u0130la\u00e7 Dairesi (FDA), Pfizer\/BioNTech veya Moderna a\u015f\u0131s\u0131 olan ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f ki\u015filere ek bir a\u015f\u0131 yap\u0131lmas\u0131n\u0131 \u00f6nerdi. Yeni mutasyonlar nedeniyle eyl\u00fcl ay\u0131ndan itibaren ba\u015fta ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 bask\u0131lanm\u0131\u015f ki\u015filer olmak \u00fczere daha geni\u015f gruplara 3. doz yap\u0131lmas\u0131 karar\u0131 al\u0131nd\u0131.<\/p>\n
Bu tavsiye kararlar\u0131 do\u011frultusunda FDA, Pfizer\/BioNTech’in geli\u015ftirdi\u011fi Covid-19 a\u015f\u0131s\u0131n\u0131n 65 ya\u015f ve \u00fczerindeki ki\u015filer, a\u011f\u0131r hastal\u0131k riski ta\u015f\u0131yan t\u00fcm ki\u015filer ve vir\u00fcse d\u00fczenli olarak maruz kalanlar i\u00e7in 3. takviye dozunun uygulanmas\u0131n\u0131 onaylad\u0131.<\/p>\n
A\u011f\u0131r hastal\u0131k riski ta\u015f\u0131yan ve 3. doz a\u015f\u0131n\u0131n \u00f6nerildi\u011fi hastal\u0131klar;<\/p>\n
\u2022 Kanser hastalar\u0131
\u2022 Kemik ili\u011fi nakli
\u2022 Solid organ nakli
\u2022 K\u00f6k h\u00fccre tedavisi
\u2022 Genetik ba\u011f\u0131\u015f\u0131kl\u0131k yetmezli\u011fi
\u2022 HIV
\u2022 V\u00fccudun baz\u0131 enfeksiyonlarla sava\u015fma yetene\u011fini azaltan ila\u00e7lar\u0131n kullan\u0131m\u0131<\/p>\n
A\u015f\u0131lar\u0131n etkinli\u011fine ili\u015fkin veriler, \u00e7ok farkl\u0131 sonu\u00e7lar ve tasar\u0131m farkl\u0131l\u0131klar\u0131 g\u00f6sterse de kabaca bir fikir veriyor. Bug\u00fcne kadarki veriler, belirli varyantlarla a\u015f\u0131 n\u00f6tralizasyon etkinli\u011finde bir d\u00fc\u015f\u00fc\u015f olmas\u0131na ra\u011fmen, a\u015f\u0131lar\u0131n ciddi hastal\u0131klar\u0131 \u00f6nlemede olduk\u00e7a ba\u015far\u0131l\u0131 oldu\u011funu g\u00f6steriyor.<\/p>\n
G\u00fcncel veriler BioNTech a\u015f\u0131s\u0131n\u0131n olu\u015fturdu\u011fu ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131n\u0131n g\u00fc\u00e7l\u00fc bir \u015fekilde 8-12 ay devam etti\u011fini g\u00f6sterdi\u011finden 2 doz BioNTech olan ki\u015filerin, 8-9 aydan \u00f6nce ek doz a\u015f\u0131 olmalar\u0131na gerek yoktur. Bu ki\u015filerde 3. doz a\u015f\u0131ya ihtiya\u00e7 olup olmayaca\u011f\u0131 ve ne zaman olaca\u011f\u0131 bu konuda yap\u0131lmakta olan \u00e7al\u0131\u015fmalar\u0131n sonu\u00e7lar\u0131na ve ortaya \u00e7\u0131kabilecek yeni varyantlara g\u00f6re belirlenecektir.<\/p>\n
Kaynak: Di\u011fer<\/p>\n","protected":false},"excerpt":{"rendered":"
2 doz mRNA a\u015f\u0131s\u0131 olanlar\u0131n g\u00fc\u00e7lendirici 3. dozu olmalar\u0131 gerekti\u011fi konusu, yap\u0131lan ara\u015ft\u0131rmalar sonras\u0131 netlik kazanmaya ba\u015flad\u0131. ABD, \u0130ngiltere ba\u015fta…<\/p>\n","protected":false},"author":2,"featured_media":17213,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,13],"tags":[],"class_list":["post-17212","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem","category-saglik"],"_links":{"self":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/17212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/comments?post=17212"}],"version-history":[{"count":0,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/17212\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media\/17213"}],"wp:attachment":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media?parent=17212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/categories?post=17212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/tags?post=17212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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