{"id":11566,"date":"2021-09-05T15:13:22","date_gmt":"2021-09-05T15:13:22","guid":{"rendered":"https:\/\/haberglobal.com.tr\/dunya\/arastirma-organlari-yilan-zehri-gibi-parcalayan-bir-enzim-covid-19-olumlerinin-sebebi-olabilir-130702"},"modified":"2021-09-05T15:13:22","modified_gmt":"2021-09-05T15:13:22","slug":"arastirma-organlari-yilan-zehri-gibi-parcalayan-bir-enzim-covid-19-olumlerinin-sebebi-olabilir","status":"publish","type":"post","link":"https:\/\/istanbulchannel.net\/index.php\/2021\/09\/05\/arastirma-organlari-yilan-zehri-gibi-parcalayan-bir-enzim-covid-19-olumlerinin-sebebi-olabilir\/","title":{"rendered":"Ara\u015ft\u0131rma: Organlar\u0131 y\u0131lan zehri gibi par\u00e7alayan bir enzim Covid-19 \u00f6l\u00fcmlerinin sebebi olabilir"},"content":{"rendered":"
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ABD\u2019deki Stony Brook \u00dcniversitesi Hastanesi ve Wake Forest T\u0131p Fak\u00fcltesi’nden ara\u015ft\u0131rmac\u0131lar\u0131n Arizona \u00dcniversitesi’yle ortak y\u00fcr\u00fctt\u00fckleri \u00e7al\u0131\u015fmada, iki Covid-19 hastas\u0131ndan al\u0131nan kan \u00f6rnekleri incelendi.<\/p>\n

Ara\u015ft\u0131rmac\u0131lar, sPLA2-11A adl\u0131 enzimin kanda dola\u015ft\u0131\u011f\u0131n\u0131 fark etti. Bu enzimin hastalar\u0131n Covid-19’dan \u00f6l\u00fcm\u00fcne ili\u015fkin \u00f6ng\u00f6r\u00fcde bulunmak i\u00e7in \u00f6nemli bir y\u00f6ntem olabilece\u011fi belirtiliyor.<\/p>\n

Journal of Clinical Investigation’da yay\u0131nlanan \u00e7al\u0131\u015fman\u0131n k\u0131demli yazarlar\u0131ndan Dr Floyd (Ski) Chilton ortaya \u00e7\u0131kan durumu \u00e7an e\u011frisine benzetiyor ve hastal\u0131\u011fa kar\u015f\u0131 direncin y\u00fckselirken vir\u00fcse kar\u015f\u0131 toleransa d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fcne dikkat \u00e7ekiyor.<\/p>\n

Chilton durumu “Bu enzim vir\u00fcs\u00fc \u00f6ld\u00fcrmeye \u00e7al\u0131\u015f\u0131yor, ancak bir noktadan sonra \u00f6yle \u00e7ok miktarda sal\u0131n\u0131yor ki, i\u015fler k\u00f6t\u00fcye gitmeye ba\u015fl\u0131yor, hastan\u0131n zar h\u00fccrelerini yok ediyor. Ve bu \u015fekilde organ yetmezli\u011fine ve \u00f6l\u00fcme sebep oluyor” \u015feklinde a\u00e7\u0131kl\u0131yor.<\/p>\n

KAN DE\u011eERLER\u0130 ELE VERD\u0130<\/strong><\/p>\n

\u00c7al\u0131\u015fman\u0131n e\u015f yazarlar\u0131ndan Prof. Maur\u0131zio Del Poeta, ara\u015ft\u0131rman\u0131n Dr Chilton’\u0131n hastal\u0131\u011f\u0131n seyrine dair olabilecek fakt\u00f6rleri tan\u0131mlamas\u0131n\u0131n ard\u0131ndan hastalardan al\u0131nan kan \u00f6rneklerinde lipit ve metabolitleri analiz etmeye ba\u015flad\u0131klar\u0131n\u0131 belirtiyor.<\/p>\n

Ara\u015ft\u0131rma ekibi binlerce hastaya ait veriyi incelemeye al\u0131yor ve ekip ya\u015f, v\u00fccut kitle endeksi ve \u00f6nceden varolan ko\u015fullar gibi geleneksel olarak risk fakt\u00f6rlerinin yan\u0131 s\u0131ra hastalar\u0131n lipit ve metabolit de\u011ferlerine de odaklan\u0131yor.<\/p>\n

Arizona \u00dcniversitesi’den Yard\u0131mc\u0131 Do\u00e7ent Dr. Justin Snider bu \u00e7al\u0131\u015fma ile hastal\u0131\u011fa yenik d\u00fc\u015fen hastalar\u0131n metabolitlerinde bir benzerlik tespit ettiklerini belirterek, ortaya \u00e7\u0131kan metabolitlerin h\u00fccrede enerji bozuklu\u011fu ve beklenmedik bir \u015fekilde y\u00fcksek dozda sPLA2-11A enzimini ortaya \u00e7\u0131kard\u0131\u011f\u0131n\u0131 kaydediyor.<\/p>\n

Analizlerde sa\u011fl\u0131kl\u0131 bir ki\u015fide bu enzim oran\u0131 bir mililitrede yakla\u015f\u0131k yar\u0131m nanogram iken, a\u011f\u0131r Covid-19 hastalar\u0131n\u0131n y\u00fczde 63’\u00fcnde bu oran 10 nanogram\u0131n \u00fczerine \u00e7\u0131k\u0131yor. Ara\u015ft\u0131rmac\u0131lar \u00f6zellikle Covid-19 dolay\u0131s\u0131yla hayat\u0131n\u0131 kaybedenlerde enzim oran\u0131n\u0131n \u00e7ok y\u00fcksek oldu\u011fa dikkat \u00e7ekiyor.<\/p>\n

“PAR\u00c7ALAYICI ENZ\u0130M\u2019 \u00c7INGIRAKLI YILAN ZEHR\u0130NDEK\u0130 ENZ\u0130ME \u00c7OK BENZ\u0130YOR”<\/strong><\/p>\n

Wake Forest T\u0131p Fak\u00fcltesi’nden ara\u015ft\u0131rmac\u0131lara g\u00f6re “par\u00e7alay\u0131c\u0131” olarak adland\u0131rd\u0131klar\u0131 enzim, sepsis gibi a\u011f\u0131r iltihaplanma vakalar\u0131nda ya da hemorajik ve kardiyojenik \u015fok gibi durumlarda s\u0131k s\u0131k g\u00f6r\u00fclen bir etki yarat\u0131yor.<\/p>\n

Daha \u00f6nce yap\u0131lan ara\u015ft\u0131rmalar enzimin \u00e7\u0131ng\u0131rakl\u0131 y\u0131lan zehrindeki temel bir enzime genetik olarak \u00e7ok benzedi\u011fini ortaya \u00e7\u0131karm\u0131\u015ft\u0131.<\/p>\n

Bilim insanlar\u0131 bu enzimin uzun Covid-19’a da yol a\u00e7\u0131p a\u00e7mad\u0131\u011f\u0131 konusunda ara\u015ft\u0131rmalar y\u00fcr\u00fct\u00fcyor.<\/p>\n

(euronews)<\/p>\n","protected":false},"excerpt":{"rendered":"

<p>ABD\u2019deki Stony Brook \u00dcniversitesi Hastanesi ve Wake Forest T\u0131p Fak\u00fcltesi'nden ara\u015ft\u0131rmac\u0131lar\u0131n Arizona \u00dcniversitesi'yle ortak y\u00fcr\u00fctt\u00fckleri \u00e7al\u0131\u015fmada, iki Covid-19 hastas\u0131ndan al\u0131nan kan…<\/p>\n","protected":false},"author":2,"featured_media":11567,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-11566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-dunya"],"_links":{"self":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/11566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/comments?post=11566"}],"version-history":[{"count":0,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/posts\/11566\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media\/11567"}],"wp:attachment":[{"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/media?parent=11566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/categories?post=11566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/istanbulchannel.net\/index.php\/wp-json\/wp\/v2\/tags?post=11566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}